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Prenatal direct exposure to scarcity affects long-lasting health and wellness

.Attribute Medication, Posted online: 09 September 2024 doi:10.1038/ d41591-024-00068-4Analysis of d...

A worldwide metric of immune health

.Attribute Medication, Published online: 05 September 2024 doi:10.1038/ s41591-024-03210-4A study us...

Niacin, food items intake as well as cardio impacts

.Attribute Medicine, Released online: 05 September 2024 doi:10.1038/ s41591-024-03220-2Niacin, food ...

Opportunities as well as difficulties for patient-reported result evaluation in multimorbidity research study and also technique

.Completing interests.S.E.H. obtains backing from the National Principle of Health as well as Treatm...

Hibernation science used to address weight problems and tweak rate of metabolism

.Nature Medication, Released online: 04 September 2024 doi:10.1038/ s41591-024-03226-wBy comprehendi...

CAR- T and also cellular gene therapies are also costly

.Nature Medicine, Released online: 04 September 2024 doi:10.1038/ s41591-024-03231-zPoint-of-care pr...

The WHO genomics course of benefit equitable execution of human genomics for international wellness

.The magazine of the first draft of the human genome pattern in 20011 was actually adhered to by the...

Advancing global antibiotic research study, progression and also accessibility #.\n\nMurray, C. J. L. et al. Global trouble of microbial antimicrobial protection in 2019: an organized analysis. Lancet 399, 629\u00e2 $ \"655 (2022 ). AMR Leaders. In the direction of details devotions and action in the reaction to antimicrobial resistance. Worldwide Leaders Group on Antimicrobial Protection https:\/\/www.amrleaders.org\/resources\/m\/item\/glg-report (4 April 2024). Globe Wellness Association. That publishes checklist of microorganisms for which brand new antibiotics are actually quickly needed. World Wellness Institution https:\/\/www.who.int\/news\/item\/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed (27 February 2017). Globe Health And Wellness Organization. WHO microbial top priority virus checklist, 2024: microbial virus of hygienics relevance to assist study, advancement and also techniques to stop and also control antimicrobial resistance. World Wellness Company https:\/\/www.who.int\/publications\/i\/item\/9789240093461 (17 May 2024). Silver, L. L. A Gestalt way to Gram-negative access. Bioorg. Medication. Chem. 24, 6379\u00e2 $ \"6389 (2016 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nSundqvist, M. Reversibility of antibiotic resistance. Ups. J. Medication. Sci. 119, 142\u00e2 $ \"148 (2014 ).\nGoogle Scholar\u00c2.\nGlobe Health Institution. 2023 anti-bacterial representatives in clinical as well as preclinical development: an outline as well as review. Planet Wellness Company https:\/\/www.who.int\/publications\/i\/item\/9789240094000 (14 June 2024). O' Neill, J. et cetera. AMR Assessment. May 19, 2016 \u00e2 $\" Handling drug-resistant contaminations around the world: final record and also suggestions. Evaluation on Antimicrobial Resistance https:\/\/amr-review.org\/Publications.html (19 May 2016). Drive-AB Consortium. DRIVE-AB outcomes: files as well as instruction. Drive abdominal https:\/\/drive-ab.eu\/drive-ab-outputs\/drive-ab-reports\/ (2016 ). Stern, S. et cetera. Breaking through the wall structure: a require collective activity on prescription antibiotics r &amp d. Boston ma Consulting Group https:\/\/www.bundesgesundheitsministerium.de\/fileadmin\/Dateien\/5_Publikationen\/Gesundheit\/Berichte\/GUARD_Follow_Up_Report_Full_Report_final.pdf (February, 2017). Anderson, M., Panteli, D. &amp Mossialos, E. Plan Short 51: Exactly how can the EU support lasting advancement as well as accessibility to efficient anti-biotics? policy options for existing as well as new medicines. European Observatory on Health Units as well as Plans https:\/\/eurohealthobservatory.who.int\/publications\/i\/how-can-the-eu-support-sustainable-innovation-and-access-to-effective-antibiotics-policy-options-for-existing-and-new-medicines (21 June 2023). Turnidge, J. &amp Christiansen, K. Antibiotic usage and resistance\u00e2 $\" confirming the noticeable. Lancet 365, 548\u00e2 $ \"549 (2005 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nWorld Health Organization. 2021 AWaRe category. WHO gain access to, view, get, distinction of prescription antibiotics for examination as well as tracking of making use of. Globe Health Organization https:\/\/www.who.int\/publications\/i\/item\/2021-aware-classification (30 September 2021). International Centre for Illness Deterrence and also Management. Antimicrobial resistance aim ats: just how can our experts reach all of them through 2030? ECDC https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/amr-brief-eaad-2023-update.pdf (2023 ). World Health And Wellness Organization. Shortage of innovation readied to weaken antibiotic functionality and also wellness gains. Planet Wellness Company https:\/\/www.who.int\/news\/item\/22-06-2022-22-06-2022-lack-of-innovation-set-to-undermine-antibiotic-performance-and-health-gains (22 June 2022). Magnano San, L. R. et cetera. How antimicrobial protection is actually linked to environment change: an outline of 2 intertwined international difficulties. Int. J. Environ. Res. Public Health 20, 1681 (2023 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nDolecek, C., Shakoor, S., Basnyat, B., Okwor, T. &amp Sartorius, B. Drug-resistant microbial infections: our experts require critical action as well as financial investment that concentrate on the weakest hyperlink. PLoS Biol. Twenty, e3001903 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nPlanet Wellness Association. Booster shot protection. World Health Institution https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/immunization-coverage (15 July 2024). Chimhini, G., Magwenzi, M. &amp Fitzgerald, F. C. Contamination avoidance and also management in low-resource settings: the demand for the local area, the contextual and also the practical. Affect. Prev. Pract. 4, 100135 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nNour, S., Stokle, E., Ashiru-Oredope, D. &amp Wesangulae, E. Difficulties of implementing antimicrobial conservation resources in reduced to center profit countries (LMICs). Affect. Prev. Pract. 5, 100315 (2023 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nAminov, R. A short background of the antibiotic age: courses found out and also obstacles for the future. Face. Microbiol. 1, 134 (2010 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nOutterson, K. et al. Person get access to in 14 high-income nations to brand new antibacterials authorized by the US Food and Drug Administration, European Medicines Firm, Japanese Pharmaceuticals and Medical Instruments Company, or Health Canada, 2010\u00e2 $ \"2020. Clin. Infect. Dis. 74, 1183\u00e2 $ \"1190 (2022 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nPlanet Wellness Institution. 2021 anti-bacterial agents in professional and preclinical growth: an outline and also study. World Health Company https:\/\/www.who.int\/publications\/i\/item\/9789240047655 (27 May 2022). Antibiotics: the business economics have to support the science. Nature 625, 7 (2024 ). Thomas, D. &amp Wessel, C. The state of advancement in antibacterial therapeutics. Medical Development Organization https:\/\/www.bio.org\/sites\/default\/files\/2022-02\/The-State-of-Innovation-in-Antibacterial-Therapeutics.pdf (February, 2022). Strich, J. et al. Determining specialist use of next-generation antibiotics versus resistant Gram-negative diseases in united state healthcare facilities: a retrospective mate research. Ann. Trainee. Med. 177, 559\u00e2 $ \"572 (2024 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nThomas, D. &amp Wessel, C. The condition of innovation in anti-bacterial therapies. Medical Technology Institution https:\/\/www.bio.org\/sites\/default\/files\/2022-04\/BIO-Antibacterial-Report-2022.pdf (February 2022). Renwick, M. J., Brogan, D. M. &amp Mossialos, E. An organized evaluation and crucial analysis of motivation approaches for exploration and advancement of unique prescription antibiotics. J. Antibiot. 69, 73\u00e2 $ \"88 (2016 ). Article\u00c2.\nCAS\u00c2.\n\nGoogle.com Scholar\u00c2.\nHealth And Wellness Unexpected Emergency Readiness as well as Response Authorization. R &amp d of clinical countermeasures. European Commission https:\/\/health.ec.europa.eu\/health-emergency-preparedness-and-response-hera\/preparedness\/research-and-development-medical-countermeasures_en (2024 ). European Payment. Pre-draft proposition for an International relationship under Perspective Europe One Health Antimicrobial Protection. European Percentage https:\/\/research-and-innovation.ec.europa.eu\/system\/files\/2022-02\/ec_rtd_he-partnerships-onehealth-amr.pdf (9 February 2022). Global Antibiotic Research and Development Partnership. Entasis Rehabs and also the International Anti-biotic Analysis &amp Progression Alliance to build a brand new therapy for gonorrhea. GARDP https:\/\/gardp.org\/entasis-therapeutics-and-the-global-antibiotic-research-development-partnership-to-develop-a-new-treatment-for-gonorrhea\/ (6 July 2017). Atal, I., Trinquart, L., Porcher, R. &amp Ravaud, P. Differential globalization of industry- and also non-industry-sponsored clinical tests. PLoS ONE 10, e0145122 (2015 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nGlobe Health Company. Number of professional test enrollments through area, health condition, stage of progression, age and also sex of trial participants (1999\u00e2 $ \"2022). World Health and wellness Institution https:\/\/www.who.int\/observatories\/global-observatory-on-health-research-and-development\/monitoring\/number-of-trial-registrations-by-year-location-disease-and-phase-of-development (February 2023). Global Anti-biotic R &amp D Collaboration. NeoSept1: a research to determine the rank of existing as well as brand new prescription antibiotics mixes to manage newborns that reside in medical facility with extreme sepsis. ISRCTN registry https:\/\/www.isrctn.com\/ISRCTN48721236 (17 January 2022). Hygienics Firm of Canada. Authorities of Canada creates necessary expenditure to overcome antimicrobial protection (AMR), Government of Canada https:\/\/www.canada.ca\/en\/public-health\/news\/2023\/05\/government-of-canada-makes-important-investment-to-fight-antimicrobial-resistance-amr.html (11 May 2023). International Prescription Antibiotic Experimentation Collaboration. Asia government financing assists GARDP\u00e2 $ s initiatives to counter antibiotic resistance. GARDP https:\/\/gardp.org\/japan-government-funding-supports-gardps-efforts-to-counter-antibiotic-resistance\/ (19 Oct 2023). Novo Nordisk Base. Novo Nordisk Groundwork companions with CARB-X to overcome drug-resistant contaminations. novo nordisk structure https:\/\/novonordiskfonden.dk\/en\/news\/novo-nordisk-foundation-partners-with-carb-x-to-fight-drug-resistant-infections\/ (9 January 2024). European Commission: European Wellness as well as Digital Executive Firm. Study on bringing AMR medical countermeasures to the marketplace. Publications Office of the European Union https:\/\/op.europa.eu\/en\/publication-detail\/-\/publication\/51b2c82c-c21b-11ed-8912-01aa75ed71a1\/language-en (2023 ). Outterson, K. Estimating the proper measurements of global pull incentives for anti-bacterial medications. Health and wellness Aff. 40, 1758\u00e2 $ \"1765 (2021 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nEvans, E. J., Meyer, A. &amp Conti, R. M. Sizing a market entry perks for the advancement of brand-new antibiotics. Harvard Kennedy Institution https:\/\/www.hks.harvard.edu\/sites\/default\/files\/centers\/mrcbg\/Final_AWP_232.pdf (May 2024). Morel, C. M. et al. Business rewards and also antibiotic protection: an overview to the antibiotic susceptibility perk. J. Antibiot. 73, 421\u00e2 $ \"428 (2020 ). CAS\u00c2.\n\nGoogle Scholar\u00c2.\nBonnifield, R. &amp Towse, A. A determined USG evolved commitment for subscription-based getting of unfamiliar antimicrobials as well as its own assumed roi. Center for Global Advancement https:\/\/www.cgdev.org\/publication\/ambitious-usg-advanced-commitment-subscription-based-purchasing-novel-antimicrobials (15 November 2022). Towse, A. &amp Silverman Bonnifield, R. G7 financial investments in brand new anti-biotics would repay \u00e2 $\" for every person. Office of Wellness Business economics https:\/\/www.ohe.org\/insight\/g7-investments-in-new-antibiotics-would-pay-off-for-everyone\/ (9 December 2022). NHS England. NHS steps up struggle versus life-threatening diseases observing productive world-first fly. NHS England https:\/\/www.england.nhs.uk\/2023\/07\/nhs-steps-up-battle-against-life-threatening-infections-following-successful-world-first-pilot\/ (11 July 2023). US Congress. S. 1355 \u00e2 $\" PASTEUR Act of 2023. congress.gov www.congress.gov\/bill\/118th-congress\/senate-bill\/1355#:~:text=This%20bill%20authorizes%20the%20Department,and%20contains%20other%20related%20provisions (27 April 2023). European Compensation. Reform of the EU pharmaceutical legalisation. European Payment https:\/\/health.ec.europa.eu\/medicinal-products\/pharmaceutical-strategy-europe\/reform-eu-pharmaceutical-legislation_en (26 April 2023). Gotham, D. et al. Repayment versions to attack market failures for antimicrobials: strategies taken in France, Germany, Sweden, the United Kingdom, as well as the USA. Health and wellness Plan 125, 296\u00e2 $ \"306 (2020 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nInternational Federation of Pharmaceutical Manufacturers and also Organizations. From resistance to resilience: what could the potential antibiotic pipe look like? IFMPA https:\/\/www.ifpma.org\/publications\/from-resistance-to-resilience-what-could-the-future-antibiotic-pipeline-look-like\/ (14 May 2024). International AMR R&ampD Hub &amp Planet Health Company. Incentivising the progression of brand new anti-bacterial therapies: 2023 report card due to the Worldwide AMR R&ampD Hub and That. Global AMR R&ampD Center https:\/\/globalamrhub.org\/publications\/incentivising-the-development-of-new-antibacterial-treatments-2023\/ (2023 ). Glover, R. E., Performer, A., Roberts, A. P. &amp Kirchhelle, C. Why is actually the UK subscription style for anti-biotics considered successful? Lancet Micro organism 4, e852\u00e2 $ \"e853 (2023 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nNon-paper \u00e2 $\" novel stimuli for the growth and keeping the market place of antimicrobials. Politico https:\/\/www.politico.eu\/wp-content\/uploads\/2022\/12\/01\/Non-paper-Transferable-exclusivity-voucher-for-AMR-2.pdf (2022 ). Liu, L. et al. Global, regional, and also nationwide root causes of kid death in 2000\u00e2 $ \"13, along with forecasts to educate post-2015 top priorities: an upgraded methodical evaluation. Lancet 385, 430\u00e2 $ \"440 (2015 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nQuadri, F. et cetera. Antibacterial drug deficiencies coming from 2001 to 2013: implications for scientific exercise. Clin. Affect. Dis. 60, 1737\u00e2 $ \"1742 (2015 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nBenhabib, A. et al. The French coverage body for medicine lacks: summary and patterns coming from 2012 to 2018: an observational retrospective research study. BMJ Open 10, e034033 (2020 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nKlein, E. Y. et cetera. Evaluation of that antibiotic usage and also access targets in 76 nations, 2000\u00e2 $ \"15: an analysis of pharmaceutical sales information. Lancet Infect. Dis. 21, 107\u00e2 $ \"115 (2021 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nPyzik, O. Z. &amp Abubakar, I. Combating the phonies: dealing with second-rate and falsified medications. Nat. Rev. Dis. Primers 8, 55 (2022 ). Hayhoe, B., Greenfield, G. &amp Majeed, A. Is it receiving easier to acquire prescription antibiotics in the UK? Br. J. Gen. Pract. 69, 54\u00e2 $ \"55 (2019 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nBlack Community for Research Laboratory Medication. Plan concise and infographics on antimicrobial protection (AMR) in Africa. ASLM https:\/\/aslm.org\/resource\/policy-brief-and-infographics-on-antimicrobial-resistance-amr-in-africa\/ (14 September 2022). Kanu, J. S. et al. National antibiotic usage for human usage in Sierra Leone (2017\u00e2 $ \"2019): a cross-sectional study. Trop. Medication. Infect. Dis. 6, 77 (2021 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nNamugambe, J. S. et al. National antimicrobial usage: review of central stockrooms items to in-patient care health and wellness facilities from 2017 to 2019 in Uganda. Trop. Medication. Corrupt. Dis. 6, 83 (2021 ).\nGoogle.com Scholar\u00c2.\nRobertson, J. et al. Variants in the consumption of antimicrobial medications in the European area, 2014\u00e2 $ \"2018: results and also implications from ESAC-Net and also That Europe. Face. Pharmacol. 12, 639207 (2021 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nShukar, S. et cetera. Drug lack: causes, impact, as well as minimization methods. Face. Pharmacol. 12, 693426 (2021 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nOutterson, K., Orubu, E. S. F., Rex, J., \u00c3 ... rdal, C. &amp Zaman, M. H. Patient accessibility in 14 high-income nations to brand-new antibacterials authorized by the US Fda, European Medicines Agency, Japanese Pharmaceuticals and also Medical Instruments Firm, or even Wellness Canada, 2010\u00e2 $ \"2020. Clin. Contaminate. Dis. 74, 1183\u00e2 $ \"1190 (2021 ). Article\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nPulcini, C. et al. Forgotten anti-biotics: a follow-up inventory research study in Europe, the USA, Canada and Australia. Int. J. Antimicrob. Brokers 49, 98\u00e2 $ \"101 (2017 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nRottingen, J. A. &amp Farrar, J. Targeted health development for international health. Br. Medication. J. 366, 15601 (2019 ).\nGoogle.com Scholar\u00c2.\nAMR Sector Collaboration. The 2023 AMR Market Alliance progression study: production as well as the atmosphere. amr Business Collaboration https:\/\/www.amrindustryalliance.org\/wp-content\/uploads\/2023\/12\/AMRIA_Manufacturing-and-the-environment-FINAL.pdf (2023 ). Munoz, V., Visentin, F., Foray, D. &amp Gaule, P. Can clinical items be actually developed on a non-profit manner? Looking into product growth collaborations for neglected health conditions. Sci. Public law 42, 315\u00e2 $ \"338 (2015 ). Article\u00c2.\n\nGoogle Scholar\u00c2.\nSwaminathan, S. et cetera. Reboot biomedical R&ampD in the international social interest. Attributes 602, 207\u00e2 $ \"210 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nAfrica Centres for Health Condition Management as well as Avoidance. Africa CDC heads vibrant transfer to get Africa\u00e2 $ s health future by creating a 50 billion buck clinical market. AfricaCDC https:\/\/africacdc.org\/news-item\/africa-cdc-spearheads-bold-move-to-secure-africas-health-future-by-creating-a-50-billion-dollar-medical-market\/ (19 February 2024). Carnage, C., Morin, S., R\u00c3 \u00b8 ttingen, J. A. &amp Kieny, M. P. Arranging public-health trademark licensing arrangements to improve access to health and wellness innovations: an insider\u00e2 $ s account. BMJ Glob. Health 8, e012964 (2023 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nSuleman, F., Low, M., Moon, S. &amp Morgan, S. G. New business designs for r &amp d with cost demands are needed to have to accomplish reasonable pricing of medications. Br. Medication. J. 368, l4408 (2020 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nCombating Antibiotic-Resistant Bacteria Biopharmaceutical Gas. Stewardship and also get access to. CARB-X https:\/\/carb-x.org\/about\/stewardship-and-access\/ (2024 ). Global Prescription Antibiotic R &amp D Alliance. Shinogi, GARDP and also CHAI announce spots license and also cooperation agreements to alleviate microbial diseases next to expanding access to cefiderocol in 135 countries. GARDP https:\/\/gardp.org\/shionogi-gardp-and-chai-announce-landmark-license-and-collaboration-agreements-to-treat-bacterial-infections-by-expanding-access-to-cefiderocol-in-135-countries\/ (15 June 2022). AMR Field Partnership. Leaving behind the laboratory: tracking the decrease in AMR R&ampD specialists. amr Business Partnership https:\/\/www.amrindustryalliance.org\/wp-content\/uploads\/2023\/02\/Leaving-the-Lab_final-1.pdf (February, 2024). G7 Wellness Ministers. G7 Health And Wellness Ministers\u00e2 $ Communiqu\u00c3 \u00a9. G7 Germany www.g7germany.de\/resource\/blob\/974430\/2042058\/5651daa321517b089cdccfaffd1e37a1\/2022-05-20-g7-health-ministers-communique-data.pdf (twenty May 2022). G20. G20 phone call to activity on antimicrobial resistance. G7G20 Documentations Data source https:\/\/g7g20-documents.org\/database\/document\/2022-g20-indonesia-sherpa-track-health-ministers-ministers-annex-g20-call-to-action-on-antimicrobial-resistance (28 October 2022). Worldwide Coalition on Aging &amp Infectious Health Conditions Society of United States. 2024 AMR readiness mark progress report. Gauging authorities action on AMR plan. Worldwide Union on Aging https:\/\/globalcoalitiononaging.com\/wp-content\/uploads\/2024\/01\/2024-AMR-Index-Progress-Report.pdf (2024 ). Food Items and Agriculture Organization of the United Nations, United Nations Setting Programme, Planet Health Institution &amp. World Organization for Creature Health. Worldwide data bank for tracking antimicrobial resistance (AMR): country self-assessment study (TrACSS). WHO https:\/\/amrcountryprogress.org\/

/map-viewindicator2.3 (2023 ). Vehicle Katwyk, S. R. &amp Outterson K. Overview: AMR belongs in the ...

Integrating liver endpoints in professional tests of cardiovascular and kidney ailment

.Attribute Medication, Released online: 03 September 2024 doi:10.1038/ s41591-024-03223-zThis Point ...